摘要 |
This invention provides a progesterone receptor antagonist of formula (1) having the structure wherein T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together to form a ring and together contain -CH2(CH2)nCH2-, -CH2CH2CMe2CH2CH2-, -O(CH2)pCH2-, -O(CH2)qO-, -CH2CH2OCH2CH2-, or -CH2CH2NR7CH2CH2-; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or COR<A>; R<A> is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or COR<B>; R<B> is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R7 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.
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申请人 |
AMERICAN HOME PRODUCTS CORPORATION;LIGAND PHARMACEUTICALS, INC.;COLLINS, MARK, A.;MACKNER, VALERIE, A.;ZHI, LIN;JONES, TODD, K.;TEGLEY, CHRISTOPHER, M.;WROBEL, JAY, E.;EDWARDS, JAMES, P. |
发明人 |
COLLINS, MARK, A.;MACKNER, VALERIE, A.;ZHI, LIN;JONES, TODD, K.;TEGLEY, CHRISTOPHER, M.;WROBEL, JAY, E.;EDWARDS, JAMES, P. |