THE USE OF ADENO-ASSOCIATED VIRUS (AAV) DELIVER CYTOPROTECTIVE GENES

摘要

This invention pertains to a method of protecting pancreatic beta -cells from immune system-mediated cell damage through transduction of the cells with an adeno-associated viral vector encoding cytoprotective genes. These protected cells are suitable for transplantation into mammals and will be protected from rejecton by the host. The method also may be used to protect pancreatic islet beta -cells in situ for the primary prevention of immune-mediated destruction which leads to Type 1 diabetes. Pancreatic beta -cells may be transduced with AAV vectors according to the invention for in vivo or ex vivo gene therapy.