发明名称 |
DEVICES AND METHODS FOR APPLYING A MIXTURE OF TWO OR MORE LIQUID COMPONENTS TO FORM A BIOMATERIAL |
摘要 |
Novel methods and devices which provide enhanced mixing and application of two liquid components to form a biomaterial with minimized aerosols is achieved using air flow rates below about 1.25 liters/minute in combination with a ratio of air flow to total liquid flow of from about 150:1 up to about 1500:1. Preferably the air flow is below about 1 liter/minute and the ratio of air flow to total liquid flow is from about 200:1 to about 1200:1. The parameters are ideally suited for the spray application of components which form a surgical sealant, e.g., a fibrin sealant. Also a part of the present invention are novel application methods for biomaterial, e.g., surgical sealant, components at liquid flows below 1.9 ml/minute, novel methods involving the mixing of such components on the exit surface of a spray tip or nozzle, novel spray tips and biomaterial applicators and methods for making such applicators. |
申请公布号 |
EP0951311(A4) |
申请公布日期 |
2000.11.08 |
申请号 |
EP19970946656 |
申请日期 |
1997.11.14 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
HOLM, NIELS, ERIK;LINNEBJERG, STEVEN;CORNWELL, RICHARD |
分类号 |
A61B17/00;A61B17/11;A61L26/00;A61M31/00;A61M35/00;B05B7/00;B05B7/08 |
主分类号 |
A61B17/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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