| 摘要 |
<p>A transdermal delivery system comprising one or more permeation enhancers and a compound selected from the group consisting of tiagabine, pharmaceutically acceptable salts or pharmaceutically acceptable C1-6-alkylesters thereof and ionpairs of tiagabine and salicylic or oleic acid, wherein the penetration enhancer is selected from the group consisting of saturated and unsaturated fatty acids and esters thereof in propylene glycol, bisabolol in ethanol/water. cineol in ethanol/water, hydroxypropyl-beta-cyclodextrin in ethanol/water or decylmethylsulfoxide in ethanol/water. The delivery system is useful in the treatment of epilepsy.</p> |
