Method for the affinity-chromatographic purification of factor VIII

摘要

PCT No. PCT/EP96/02746 Sec. 371 Date Dec. 22, 1998 Sec. 102(e) Date Dec. 22, 1998 PCT Filed Jun. 24, 1996 PCT Pub. No. WO97/49730 PCT Pub. Date Dec. 31, 1997The invention concerns a process for the purification of factor VIII by affinity chromatography characterized in that a biological fluid containing factor VIII is contacted with immobilized cellular von Willebrand factor or a derivative thereof under such conditions that factor VIII is adsorbed to the immobilized von Willebrand factor or derivative thereof, impurities are separated and adsorbed factor VIII is eluted.