Pharmaceutical composition which is stable during storage and contains a thymus extract

摘要

PCT No. PCT/DE97/01142 Sec. 371 Date Nov. 25, 1998 Sec. 102(e) Date Nov. 25, 1998 PCT Filed Jun. 3, 1997 PCT Pub. No. WO97/46245 PCT Pub. Date Dec. 11, 1997The invention concerns a process for preparing a pharmaceutical composition of thymus factors which displays immunomodulating and anti-inflammatory properties and is stable during storage. The process comprises the extraction of a homogenized thymus tissue and subsequent repeated ultrafiltration via a filter membrane having an exclusion volume of 30 kD. The resultant first ultrafiltrate is then subjected to a second ultrafiltration process on a membrane having an exclusion volume of 3 kD, the retentate being used. A composition prepared in this way, in contrast to the first ultrafiltrate obtained on leukocyte cultures stimulated by phytohaemagglutinin, displays a great increase in the production of anti-inflammatory IL-10 and a reduction in the formation of inflammation-promoting IL-2 and IFN-gamma.