ANTICANCER (IV) COMPLEXES FOR ORAL ADMINISTRATION AND METHOD FOR PRODUCING SAME

摘要

PURPOSE: Anticancer (iv) complexes excellent in lipoid solubility when orally administered and absorbable in the stomach and the intestinal and process for preparation thereof by oxidizing diamine platinum complexes with hydrogen oxide and carrying out an electrophilic substitution reaction of four hydroxyl groups of the obtained diaminetetrahydroxyplatinum are provided which exhibit excellent anticancer effect. CONSTITUTION: Platinum complexes for oral administration represented by the structural formula (I) are prepared. In formula A-A is a symmetrical diamine that can chelate to platinum and is selected from the group consisting of ethylene diamine, t(+/-)-1,2-diaminocyclohexane, 2,2-dimethyl-1,3-propanediamine, cyclohexane-1,1-dimethaneamine and tetrahydro-4H-pyran-4,4-dimethaneamine; and R is propionyl, butyryl or valeryl. These complexes are useful in the treatment of cancer.