发明名称 |
Protease activated receptor 2 variants |
摘要 |
A variant PAR-2 receptor polypeptide or a fragment thereof is provided which (i) has reduced sensitivity to trypsin as compared with wild type PAR-2; (ii) has increased sensitivity to trans-cinnamoyl-LIGRLO-NH2 as compared with wild type PAR-2; and (iii) is activated by TLIGRL-NH2, which polypeptide or fragment thereof comprises an extracellular loop 2 (ECL-2) having at least one amino acid difference from the corresponding ECL-2 amino acid sequence of the wild type polypeptide. |
申请公布号 |
AU4581200(A) |
申请公布日期 |
2000.11.02 |
申请号 |
AU20000045812 |
申请日期 |
2000.04.17 |
申请人 |
UNIVERSITY OF SOUTHAMPTON |
发明人 |
ANDREW FINLAY WALLS;KAREN-JANE PALMER;STEVEN JOHN COMPTON;JENNIFER ANN CAIRNS;ALAN CHARLES GOUGH |
分类号 |
G01N33/50;A61K45/00;A61P1/04;A61P9/12;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P29/00;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12Q1/68;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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