Ppgpp and pppgpp as immunomodulatory agents

摘要

The present invention relates generally to the fields of immunopreventive therapy and vaccine development. More particularly, it concerns compositions and methods of use of the bacterial nucleotides ppGpp and pppGpp and their analogs as adjuvants that can be used to generate more potent and robust vaccines in a shorter period of time, was well as antibodies produced using the disclosed compositions and methods. The inventor has found novel immunomodulatory activities for this group of nucleotides.