| 摘要 |
Percutaneous absorption preparations comprising oxybutynin or its salt as th e active component, and, as the base component, an N-vinylacetamide copolymer containing as the major component a polymerizable monomer having N- vinylacetamide and a COOM group (wherein M represents hydrogen, an alkali metal or ammonium). The preparations are non-aqeous preparations containing, as another base component, a stabilizer comprising a crosslinking agent, polyhydric alcohols and a pH regulating agent, optionally together with a percutaneous absorption promoter and/or solvent. These preparations may be water-containing preparations which further contain an aqueous polymer compound and water. These preparations are excellent in the percutaneous absorbability of the active component and drug stability, show little skin irritation and exhibit an excellent drug effect.
|
