| 摘要 |
<p>Preventives/remedies for angiostenosis which contain compounds having an Rho kinase inhibitory activity. Compounds having an Rho kinase inhibitory activity such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)cyclohexane have various effects of suppressing the proliferation of endometrium regenerated after vascular lesion and the like. Owing to these effects, the above compounds are useful as preventives/remedies for angiostenosis, more particularly, angiostenosis induced by vascular wall lesion (for example, angiorestenosis following percutaneous coronary arterioplasty, angiorestenosis following percutaneous arterioplasty, angiostenosis following revascularization by indwelling a DCA or a stent, and angiostenosis following organ transplantation).</p> |
