| 发明名称 |
THERAPEUTIC QUASSINOID PREPARATIONS WITH ANTINEOPLASTIC, ANTIVIRAL, AND HERBISTATIC ACTIVITY |
| 摘要 |
<p>The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells. <IMAGE></p> |
| 申请公布号 |
EP0792148(A4) |
申请公布日期 |
2000.11.02 |
| 申请号 |
EP19950944025 |
申请日期 |
1995.11.03 |
| 申请人 |
ADVANCED RESEARCH & TECHNOLOGY INSTITUTE;PURDUE RESEARCH FOUNDATION;THE BOARD OF GOVERNORS |
发明人 |
GRIECO, PAUL, A.;MORRE, D., JAMES;CORBETT, THOMAS, H.;VALERIOTE, FREDERICK, A. |
| 分类号 |
C07D493/04;A01N43/16;A01N43/90;A01N65/00;A61K31/35;A61K31/365;A61K31/366;A61P31/12;A61P35/00;C07D493/08;C07D493/10;(IPC1-7):A61K31/35 |
主分类号 |
C07D493/04 |
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