DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS

摘要

This invention is directed to diaryl acid derivatives of formula (I) and the ir pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor wherein: (a) and (b) are independently aryl, fused arylcycloalkenyl, fused arylcycloalkyl, fused arylheterocyclenyl, fused arylheterocyclyl, heteroaryl, fused heteroarylcycloalkenyl, fused heteroarylcycloalkyl, fused heteroarylheterocyclenyl, or fused heteroarylheterocyclyl; A is -O-, -S-, -SO-, SO2-, -NR13-, -C(O)-, -N(R14)C( O)- , -C(O)N(R15)-, -N(R14)C(O)N(R15)-, -C(R14)=N-, (c), (d), (e), a chemical bond, (f) or (g), B is -O-, -S-, -NR19- a chemical bond, -C(O)-, -N(R20)C(O) -, or -C(O)N(R20)-; Z is R21O2C-, R21OC-, cyclo-imide, -CN, R21O2SHNCO-, R21O2S HN- , (R21)2NCO-, R21O-2,4-thiazolidinedionyl, or tetrazolyl.