发明名称 |
Method for identification of cryptic peptides |
摘要 |
The invention provides a method of determining whether a peptide of a protein is a cryptic peptide epitope, which method includes the steps of: i) exposing T cells to the peptide in a primary challenge; ii) measuring the reactivity of T cells with the peptide in the primary challenge of step i); iii) exposing pre-challenged T cells with the peptide in a secondary challenge, wherein the pre-challenged T cells are obtainable by exposing the T cells to the protein; and measuring the reactivity of the pre-challenged T cells with the peptide in the secondary challenge of step iii), and the peptide is a cryptic peptide if T-cell reactivity is observable in the secondary challenge but not in the primary challenge.
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申请公布号 |
GB2349463(A) |
申请公布日期 |
2000.11.01 |
申请号 |
GB20000020260 |
申请日期 |
1997.03.20 |
申请人 |
* CIRCASSIA LTD |
发明人 |
ANTHONY BARRINGTON * KAY;MARK * LARCHE |
分类号 |
C12Q1/02;A61K31/00;A61K38/00;A61K39/35;A61P11/00;A61P11/06;A61P37/00;A61P37/02;A61P37/08;C07K7/08;C07K14/37;C07K14/415;C07K14/435;C07K14/47;G01N33/15;G01N33/50;G01N33/569;G01N33/68;(IPC1-7):G01N33/50;A61K38/04 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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