发明名称 |
Nucleic acid encoding human neuronal calcium channel subunits |
摘要 |
Nucleic acids encoding each of three subunits, alpha 1B, alpha 2 delta , and beta 3, of a calcium channel, are disclosed. Also disclosed are vectors containing the nucleic acids encoding the subunits; host cells containing the nucleic acids encoding the subunits; methods of isolating nucleic acids encoding related calcium channel subunits; the subunit proteins; fusion proteins comprising the subunit proteins; antibodies to the subunit proteins; assays to identify agents that modulate calcium channel activity, and agents identified thereby; methods of treating certain central nervous system disorders by altering calcium channel activity; and methods of diagnosing diseases associated with particular calcium channels, such as Lambert-Eaton syndrome.
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申请公布号 |
US6140485(A) |
申请公布日期 |
2000.10.31 |
申请号 |
US19990452007 |
申请日期 |
1999.11.30 |
申请人 |
AMERICAN HOME PRODUCTS CORP. |
发明人 |
FRANCO, RODRIGO;CHEN, AI RU SUN;SHUEY, DAVID JOHN |
分类号 |
C07K14/705;(IPC1-7):C07H21/02 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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