SUGAR CHAIN CALCITONIN DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain the subject new compound useful as a medicine by replacing 26-position aspartic acid to an N-bond type sugar chain-containing asparagine residue. SOLUTION: This calcitonin derivative is obtained by replacing 26-position aspartic acid to an N-bond type sugar chain-containing asparagine residue. The derivative is preferably an eel calcitonin derivative, more preferably an eel calcitonin derivative obtained by replacing an 26-position aspartic acid of the formula I [R is (NeuAc-Gal-GlcNAc-Man)2-Man-G1cNAc, (Gal-GlcNac- Man)2-Man-GlcNac or Man6-GlcNac (NeuAc is sialic acid); Gal is D-galactose; GlcNAc is N-acetyl-D-glucosamine; and Man is D-mannose] to an N-bond type sugar chain-containing asparagine residue. The derivative can be synthesized by subjecting a saccharide-eel calcitonin derivative of formula II to sugar chain transfer reaction of enzyme endoglycosidase.