| 摘要 |
PROBLEM TO BE SOLVED: To efficiently obtain isoprenoid compounds that is useful for treatment of heart diseases, osteoporosis and the like in high yield by culturing a specific transformant in a medium. SOLUTION: A DNA including one or more DNAs selected from (A) a DNA encoding a protein having the activity of catalyzing the reaction forming 1- deoxy-D-xylose 5-phosphate from pyruvic acid and glyceraldehyde-5-phosphate, (B) a DNA encoding farnesyl pyrophophate synthetase, (C) a DNA encoding a protein having the amino acid sequence of the formula I or the like, (D) a DNA encoding the protein having the amino acid sequence of formula II or the like and (E) a DNA encoding the protein having the activity of catalyzing the reaction forming 2-C-methyl-D-erythritol-4-phosphate from 1-deoxy-D-xylose-5- phosphate are incorporated into a vector and the resultant vector is transduced into the host cells. Then, the resultant transformant is culture in a medium to form the objective isoprenoid compound. |
