Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts. The effectiveness of such compositions can be demonstrated in standard tests, for example by measuring tooth mobility.
申请公布号
WO0018230(A9)
申请公布日期
2000.10.26
申请号
WO1999US22199
申请日期
1999.09.24
申请人
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK