DETECTING AND SUPPRESSING MALIGNANCY BASED ON EXPRESSION OF SPLEEN TYROSINE KINASE (SYK)

摘要

Methods for detecting and treating cancers, especially breast cancer for which a malignant phenotype is characterized by loss of Syk expression are provided. Specifically, it has been found that Syk is a potent modulator of the proliferation of epithelial cells, and a suppressor of certain epithelial tumors, especially breast carcinomas.