| 发明名称 |
USE OF GLUCOSYLCERAMIDE SYNTHESIS INHIBITORS IN THERAPY |
| 摘要 |
The present invention relates to the treatment of conditions such as Niemann - Pick C storage disease, Alzheimer's disease, epilepsy, stroke and Parkinson' s disease, and in particular to the use of inhibitors of glucosylceramide synthesis in such treatment. Preferred inhibitors of glucosylceramide synthesis are imino sugar-structured, and include N-butyldeoxynojirimycin (N B- DNJ), N-butyldeoxygalactonojirimycin (NB-DGJ) and N-nonyldeoxynojirimycin (N N- DNJ).
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| 申请公布号 |
CA2368814(A1) |
申请公布日期 |
2000.10.26 |
| 申请号 |
CA20002368814 |
申请日期 |
2000.04.20 |
| 申请人 |
OXFORD GLYCOSCIENCES (UK) LIMITED |
发明人 |
HOLT, GORDON D.;WALKLEY, STEVEN |
| 分类号 |
A61K45/00;A61K31/00;A61K31/445;A61K31/5375;A61K31/70;A61K31/7008;A61K31/7088;A61K31/715;A61K38/00;A61K45/06;A61P1/16;A61P3/00;A61P9/10;A61P25/00;A61P25/08;A61P25/16;A61P25/28;A61P43/00;(IPC1-7):A61K31/445;A61K31/537 |
主分类号 |
A61K45/00 |
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