| 摘要 |
2,4-Diamino-pyrimidine derivatives (I) are new. 2,4-Diamino-pyrimidine derivatives of formula (I) and their addition salts and metal salt complexes are new. R<1> = CF3; CHF2; CClF2; CH3; OCH3; OCF3; SCH3; SCF3; CH3SO; CH3SO2; CN; Cl; Br; COOH; CONH2 or alkoxycarbonyl; R<2> = halo; CN or NO2; R<3> = H; alkyl; OH; alkoxy; NH2; NH(alkyl); N(alkyl)2; CH3SO2; COCH3; COOH; alkoxycarbonyl; CONH2; alkyl-NH-CO or CF3CO; R<4> = cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryl or heteroarylalkyl (each optionally substituted); R<5>, R<6> = H; alkyl; CH3SO2; COCH3; COOH; alkoxycarbonyl; CONH2; alkyl-NH-CO or CF3CO or R<5> + R<6> = 4-6C alkylene or (CH2)2-O-(CH2)2 or R<1> = CF3; CHF2; CClF2; CH3; OCH3; OCF3; SCH3; SCF3; CH3SO2; CN; Cl; Br; COOH; CONH2; or alkoxycarbonyl; R<2> = H; R<3> = H; alkyl; OH; alkoxy; NH2; NH(alkyl); N(alkyl)2; CH3SO2; COCH3; COOH; alkoxycarbonyl; CONH2; alkyl-NH-CO or CF3CO; R<4> = cycloalkyl, aryl, aralkyl, aryloxyalkyl, heteroaryl or heteroarylalkyl (each optionally substituted); R<5> = H and R<6> = CH3SO2 or CF3CO. Independent claims are also included for the following: (1) preparation of (I); (2) new 4-halo-2-amino-pyrimidine compounds of formula (II); (3) new 4-hydroxy-pyrimidine compounds of formula (VIII); (4) preparation of compounds (II) and (5) preparation of compounds (VIII). X, Z = Cl or Br.
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