The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.
申请公布号
WO0062813(A2)
申请公布日期
2000.10.26
申请号
WO2000CA00451
申请日期
2000.04.20
申请人
THE UNIVERSITY OF BRITISH COLUMBIA;CULLIS, PIETER, R.;CHEN, TAO;FENSKE, DAVID, B.;PALMER, LORNE, R.;WONG, KIM
发明人
CULLIS, PIETER, R.;CHEN, TAO;FENSKE, DAVID, B.;PALMER, LORNE, R.;WONG, KIM