ENT-STEROIDS AS SELECTIVELY ACTIVE ESTROGENS

摘要

This invention describes the new ent-steroids of general formula (I) in whic h R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R19 have the meanings that are indicated in the description, as pharmaceutical active ingredients that in vitro have a higher affinity to estrogen receptor preparations of rat prostates than to estrogen receptor preparations from rat uteri and in vivo preferably a preferential action on bone rather than the uterus and/or pronounced action with respect to stimulation of the expression of 5HT2a- receptors and transporters, their production, their therapeutic use and pharmaceutical forms for dispensing, which contain the new compounds. The invention also describes the use of steroids, on which the (8.alpha.-H, 9.beta.-H, 10.alpha.-H, 13.alpha.-H, 14.beta.-H)-gonane skeleton is based, f or treatment of estrogen-deficiency-induced diseases and conditions.