发明名称 |
UTEROGLOBIN IN THE TREATMENT OF IGA MEDIATED AUTOIMMUNE DISORDERS |
摘要 |
Uteroglobin has been discovered to prevent IgA mediated diseases, such as Ig A nephropathy, by preventing the deposition of IgA-Fibronectin immunocomplexes in tissues such as the renal glomeruli. The invention therefore includes methods of treating such diseases by administering therapeutically effective amounts of uteroglobin (and variants or mimetics) to prevent or improve the IgA mediated condition. Transgenic uteroglobin knockout animals, and animals in which uteroglobin-protein expression is reduced by antisense technology, also provide systems for studying IgA mediated diseases, and screening for appropriate treatments. |
申请公布号 |
CA2370738(A1) |
申请公布日期 |
2000.10.26 |
申请号 |
CA20002370738 |
申请日期 |
2000.04.13 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRE |
发明人 |
ZHANG, ZHONGJIAN;MUKHERJEE, ANIL B.;ZHENG, FENG |
分类号 |
A61K38/17;A61P9/00;A61P29/00;A61P31/12;C07K14/47;C07K16/00;C12Q1/68;(IPC1-7):A61K38/17;A01K67/00;A61P11/00;C12N15/12;G01N33/50;A61K31/56;G01N33/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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