发明名称 |
Aged skin equivalent, methods of preparation and uses thereof |
摘要 |
<p>Aged skin equivalent comprising an epidermis equivalent and an aged dermis equivalent, is new. Independent claims are also included for the following: (1) an aged dermis equivalent comprising glycated collagen and fibroblasts; (2) an epidermis equivalent that is obtainable by seeding keratinocytes onto a dermis equivalent comprising glycated collag and fibroblasts and/or has modified integrin beta 1 expression, especially expressing integrin beta 1 in the cells of at least the first three suprabasal layers; and (3) production of an aged skin equivalent by preparing a lattice comprising glycated collagen and fibroblasts and reconstituting an epidermis equivalent comprising keratinocytes on the lattice.</p> |
申请公布号 |
EP1046402(A1) |
申请公布日期 |
2000.10.25 |
申请号 |
EP20000401073 |
申请日期 |
2000.04.18 |
申请人 |
L'OREAL |
发明人 |
PAGEON, HERVE;ASSELINEAU, DANIEL;TACHON, PIERRE |
分类号 |
A61L27/36;A61L27/00;A61L27/24;A61L27/38;A61L27/60;C12N5/071;C12R1/91;G01N33/50;(IPC1-7):A61L27/00;C12N5/06 |
主分类号 |
A61L27/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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