发明名称 1-piperidinyl-propan-2-derivatives and their use as therapeutic agents
摘要 The present invention relates compounds of the formula (I): wherein R1 and R2 each independently represents a phenyl group optionally substituted by a variety of substituents; R3 represents a variety of substituents; R4, R5, R6, and R7 each independently represents hydrogen or C1-6alkyl; A represents -O- or -S-; B represents -O-, -S-, -NRa- or -CHRa-; and n is zero, 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt or a prodrug thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.
申请公布号 US6136824(A) 申请公布日期 2000.10.24
申请号 US20000511002 申请日期 2000.02.22
申请人 MERCK SHARP & DOHME LTD. 发明人 MACLEOD, ANGUS MURRAY;SWAIN, CHRISTOPHER JOHN;VAN NIEL, MONIQUE BODIL
分类号 A61P25/00;A61P29/00;C07D211/22;C07D405/12;(IPC1-7):A01N43/40 主分类号 A61P25/00
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