Process for modifying stationary carrier phases containing silanol or silanol groups with calixarenes for chromatography

摘要

PCT No. PCT/DE97/00180 Sec. 371 Date Dec. 12, 1997 Sec. 102(e) Date Dec. 12, 1997 PCT Filed Jan. 23, 1997 PCT Pub. No. WO97/27479 PCT Pub. Date Jul. 31, 1997The invention relates to a method for the modification of stationary phases which contain silanol groups with calixarene for chromatography. The silanol groups in these phases, preferably silica gel or glass, are, according to the invention, first reacted with a dialkylsilane so that a maximum number of the silanol groups of the stationary phase is modified, and then linkage takes place, by means of heterogeneous hydrosilylation, between an olefinic group which is present in the calixarene and the silane functionality of the prepared stationary phase in the presence of one or more noble metal catalysts. The invention's area of application is in column chromatography, including HPLC, thin-layer chromatography, including HPTLC, and thick-layer chromatography and gas chromatography with packed columns.