发明名称 |
PROCESS FOR PRODUCING S(+)-IBUPROFEN PARTICLES |
摘要 |
A process for the production of S(+)-ibuprofen-particles having improved flow properties comprises the steps that coarse-crystalline S(+)-ibuprofen is molten and then in a molten condition is finely distributed in a non-solving medium, preferably in cold water, and is chilled therein. This chilling results in a finecrystalline primary structure that agglomerates to a secondary structure. In this agglomerate form the product is obtained which is filtered out and is dried. Such particles are suitable for direct pressing of tablets, optionally, tableting auxiliary substances being added, also for the production of tablets having a retarded release of the active substance.
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申请公布号 |
CA2181810(C) |
申请公布日期 |
2000.10.24 |
申请号 |
CA19952181810 |
申请日期 |
1995.01.26 |
申请人 |
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发明人 |
MOELLER, TORSTEN;HANTICH, GERHARD;HESSE, ERNST |
分类号 |
A61K9/14;A61K9/16;A61K31/135;A61K31/19;A61K47/32;A61K47/38;(IPC1-7):C07C57/30;A61K9/22;C07C51/43 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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