发明名称 |
Recombinant anti-CD4 antibodies for human therapy |
摘要 |
Chimeric antibodies specific to human CD4 antigen, DNA encoding, pharmaceutical compositions containing and use thereof as therapeutic agents are taught. These chimeric antibodies contain Old World monkey variable sequences and human constant domain sequences, preferably human gamma 1, gamma 4 or mutated forms thereof. These antibodies possess desirable therapeutic properties including low antigenicity, reduced (or absent) T cell depleting activity, good affinity to human CD4 and enhanced stability (in vivo half-life).
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申请公布号 |
US6136310(A) |
申请公布日期 |
2000.10.24 |
申请号 |
US19950523894 |
申请日期 |
1995.09.06 |
申请人 |
IDEC PHARMACEUTICALS CORPORATION |
发明人 |
HANNA, NABIL;NEWMAN, ROLAND ANTHONY;REFF, MITCHELL ELLIOT |
分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K39/395;A61P11/00;A61P11/06;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/02;C07K16/00;C07K16/28;C07K16/46;C12N15/00;C12N15/13;C12P21/08;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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