发明名称 |
Water-soluble trioxanes as potent and safe antimalarial agents |
摘要 |
Biologically-active, water soluble, 3-substituted trioxanes of the formula wherein R represents a COOH- substituted aryl group, a substituted or unsubstituted heteroaryl group or an alkyl group, and C12-(p-carboxy)benzyloxy trioxanes of formula wherein R represents a substituted or unsubstituted alkyl, alkenyl, aryl or heteroaryl group and methods for their use as antiparasitic agents, particularly for the treatment of malaria.
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申请公布号 |
US6136847(A) |
申请公布日期 |
2000.10.24 |
申请号 |
US19990287353 |
申请日期 |
1999.04.07 |
申请人 |
JOHNS HOPKINS UNIVERSITY |
发明人 |
POSNER, GARY H.;PARKER, MICHAEL H.;KRASAVIN, MIKHAIL;SHAPIRO, THERESA A. |
分类号 |
A61K31/335;A61P33/06;C07D493/10;(IPC1-7):A61K31/335;A61K31/357;C07D323/06 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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