发明名称 |
VACCINE |
摘要 |
A non-naturally occurring variant of a C-terminal fragment of a Plasmodium merozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurring Plasmodium MSP-1 19, for at least one first antibody capable of blocking the binding of a second antibody, which second antibody inhibits the proteolytic cleavage of Plasmodium MSP-1 42 and (ii) substantially the same affinity for at least one third antibody compared with said naturally occurring Plasmodium MSP-1 19. which third antibody inhibits the proteolytic cleavage of Plasmodium MSP-1 42 is provided for use in an anti-malarial vaccine.
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申请公布号 |
CA2271451(A1) |
申请公布日期 |
2000.10.20 |
申请号 |
CA19992271451 |
申请日期 |
1999.05.25 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
BIRDSALL, BERRY;FEENEY, JAMES;HOLDER, ANTHONY;MORGAN, WILLIAM;UTHAIPIBULL, CHAIRAT;SYED, SHABIH |
分类号 |
A61K39/015;C07K14/445;C07K16/20;C07K19/00;C12N15/30;C12N15/62;(IPC1-7):C12N15/30 |
主分类号 |
A61K39/015 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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