| 摘要 |
medicine, endocrinology. SUBSTANCE: invention relates to method of preparing suspension of porcine protamine-insulin in cartridge that is sustained-release preparation used in therapy of diabetes mellitus. Preparation that is able for prolonged storage is prepared by mixing four solutions in injection water in the definite sequence. Injection water has the following components: phenol and m-cresol, protamine sulfate and glycerol, substance of porcine monocomponent insulin and glycerol, phenol, m-cresol, sodium hydrogen phosphate dihydrate and 1 M hydrochloric acid (to pH 7.5-7.7). Then method involves filtration of mixture of solutions, addition of injection water to final insulin concentration 100 IU/ml, crystallization at 20-26 C and pouring the preparation into cartridges. Method provides safety of physical-chemical and biological properties of preparations. EFFECT: improved method of preparing. 3 cl, 1 tbl, 2 ex |
