| 摘要 |
<p>The invention encompasses methods for identifying substances that inhibit infection by a herpesvirus and preventative and therapeutic compounds that constitute treatment or prevention of herpesvirus infections using one or more regions of US1.5 containing a posttranslational modification site that is required to be modified to effect progression of virus infection. The screening method of the invention involves a comparative analysis of the phosphorylation state of a polypeptide containing a US1.5 phosphorylation site that has been exposed to a kinase in the presence and absence of a candidate inhibitor. The compounds of the invention include US1.5 polypeptides and peptides, and their corresponding polynucleotides, that can be used to inhibit the posttranslational modification of US1.5, thus interfering with the progression of herpesvirus infection. A method of inhibiting infection is also disclosed and is directed at providing a cell with an inhibitor of US1.5 phosphorylation. Other therapeutic and preventative compounds and methods are also directed at polypeptides that bind to a US1.5 phosphorylation site.</p> |
