TREATMENT OF MYELOMA BONE DISEASE WITH PROTEASOMAL AND NF-KBACTIVITY INHIBITORS

摘要

The present invention involves the identification and use of compositions fo r treating myeloma bone disease. The compositions inhibit proteasomal activity and decrease the activity of the transcription factor NF-~B. Assessment of a candidate compound for its ability to inhibit production or activity of proteasomal enzymes or NF-~B provides a useful means to identify agents to treat myeloma bone disease.