SOLUBILIZED PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION

摘要

The invention refers to an aqueous pharmaceutical composition for parenteral use, said composition comprising i) as active substance a vitamin D or a vitamin D analogue having a solubility in water of <=0.1 % w/v at room temperature, and which is susceptible to gradation in an aqueous acidic environment, ii) a non-ionic solubilizer capable of solubilizing said active substance, the solubilizer being a low histamine-releaser and containing a fatty acid ester of polyethylene glycol optionally in admixture with a polyethylene glycol and having no negative effect on the stability of the active substance in the final composition determined as described herein, an d iii) an aqueous vehicle. Moreover, this invention refers to the use of a polyethylene glycol ester as a non-ionic solubilizer.