METHODS AND COMPOSITIONS USEFUL FOR TARGETING ACTIVATED VITRONECTIN RECEPTOR alpha v beta 3

摘要

The present invention provides ligands which can selectively bind to activated alpha v beta 3 integrin. A novel monovalent ligand-mimetic (WOW-1 Fab) which includes a single alpha v integrin-binding domain from multivalent adenovirus penton base is provided. Further, the present invention describes particular compositions of activated alpha v beta 3-specific ligands, such as an antibody which immunoreacts preferentially with activated alpha v beta 3 integrin. The invention also describes methods using an activated alpha v beta 3-specific ligand for diagnostic detection of activated alpha v beta 3 integrin in tissues and for the targeted delivery of therapeutic agents to tissues containing activated alpha v beta 3 integrin.