RADIOENHANCED CANCER TREATMENT USING ORALLY ADMINISTERED CAMPTOTHECIN DERIVATIVES

摘要

Disclosed is a method of enhancing the therapeutic effect of radiation in a host being treated for cancer including coadministering the radiation and an orally dosed camptothecin derivative to the host being treated for cancer. Also disclosed is a method of enhancing the therapeutic effect of radiation in a host being treated for cancer including orally dosing the host being treat ed for cancer with a camptothecin derivative; and administering radiation at a point when a serum concentration of the camptothecin derivative in the host being treated for cancer reaches about 50 % or more of the maximum concentration achieved by the oral dose.