发明名称 |
MULTIPLE LIQUID FLOW ELECTROSPRAY INTERFACE |
摘要 |
An apparatus for electrospray ionization of a liquid sample matrix to prepare the sample for introduction into a mass spectrometer. The inventive electrospray interface is arranged between a source of a liquid sample matrix and an electrospray ionization needle. The interface includes a central chamber which contains elements for passively mixing the liquid sample flow with a modifying liquid added to the central chamber through a side channel. The side channel is isolated from the central chamber by a flow restrictor and the modifying liquid is provided to the side channel through a valve. A second valve, side channel, and flow restrictor are used to permit introduction of a calibration fluid into the central chamber through the first side channel. The inventive interface permits mixing of a modifying liquid with the liquid sample matrix to assist in nebulization of the liquid sample by reducing the surface tension of the sample containing fluid. |
申请公布号 |
WO0018256(A3) |
申请公布日期 |
2000.10.19 |
申请号 |
WO1999US22447 |
申请日期 |
1999.09.27 |
申请人 |
VARIAN, INC. |
发明人 |
WELLS, GREGORY, J.;TONG, ROGER, C.;YEE, PETER, P. |
分类号 |
G01N27/62;G01N30/72;H01J49/04;H01J49/10 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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