摘要 |
PROBLEM TO BE SOLVED: To carry out an optical purification of the salt of 2-methyl-1-(4- trifluoromethylphenyl)-3-pyrrolidino-1-propanone in a high yield and purity without causing recemization during the purification process by suspending a mixture of a specific racemic salt of methyltrifluoromethylphenyl-pyrrolidinopropanone and an optically active isomer of the salt in an organic solvent. SOLUTION: A mixture of (A) a racemic salt of 2-methyl-1-(4- trifluoromethylphenyl)-3-pyrrolidino-1-propanone and (B) an optically active isomer of the salt is suspended in an organic solvent (preferably ketones, especially acetone, etc.), to collect the component B as the crystal and the component A as the solution. The salt is preferably hydrochloride. For example, acetone is added to (-)-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone hydrochloride having an optical purity of 80% and the precipitated crystal is filtered to obtain the purified salt having an optical purity of 99.4%. |