发明名称 |
Humanized anti-IL-8 monoclonal antibodies |
摘要 |
Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.
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申请公布号 |
US6133426(A) |
申请公布日期 |
2000.10.17 |
申请号 |
US19980026985 |
申请日期 |
1998.02.20 |
申请人 |
GENENTECH, INC. |
发明人 |
GONZALEZ, TANIA N.;LEONG, STEVEN R.;PRESTA, LEONARD G. |
分类号 |
A61K47/48;C07K16/24;(IPC1-7):C07K16/24 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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