METHOD AND INTERMEDIATE FOR PRODUCING ANTICANCER COMPOUND

摘要

PROBLEM TO BE SOLVED: To obtain an anticancer compound in a high yield useful for treating a highly proliferative disorder such as cancer in mammals by using a specific synthetic intermediate. SOLUTION: (A) A compound of formula I [R1 and R2 are each a 1-10C alkyl, a 1-10C alkoxy, preferably R1 and R2 are each 2-methoxyethoxy; R15 is H, a 1-10C alkyl or the like, preferably H; G is C(OH)R3R4 or SiR3R4R5 (R3 to R5 are each a 1-6C alkyl)] is treated, (B) in the case of G being C(OH)R3 R4, with an alkaline (earth) metal hydroxide in a hydroxy-substituted 1-10C alkyl-containing solvent or, (C) in the case of G being SiR3R4R5, with a tetra (1-6C alkyl)ammonium fluoride compound in an aprotic solvent to give a compound of formula II. The compound of formula I can be obtained by treating a compound of formula III with a compound of formula IV.