Inhibitors of UDP-G1cNAc:Ga1 beta 1-3Ga1NAc alpha R beta 1-6 N-acetylglucosaminyltransferase (core 2 G1cNAc-T) and use of the inhibitors to prevent or treat cardiomyopathy associated with diabetes

摘要

Cardiomyopathy associated with diabetes and hyperglycemia can be treated by administering to a subject suffering from this condition a substance that inhibits UDP-GlcNAc:Gal beta 1-3GalNAc alpha R beta 1-6-N-acetylglucosaminyl transferase (core 2 GlcNAc-T) activity.