发明名称 |
Enzymatic synthesis of chiral amines using -2-amino propane as amine donor |
摘要 |
2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.
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申请公布号 |
US6133018(A) |
申请公布日期 |
2000.10.17 |
申请号 |
US19990266100 |
申请日期 |
1999.03.10 |
申请人 |
CELGRO |
发明人 |
WU, WEI;BHATIA, MOHIT B.;LEWIS, CRAIG M.;LANG, WEI;WANG, ALICE L.;MATCHAM, GEORGE W. |
分类号 |
C12P13/00;C12P41/00;(IPC1-7):C12P13/00;C12P13/02;C12P13/04;C12P13/22;C12P13/24 |
主分类号 |
C12P13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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