摘要 |
PROBLEM TO BE SOLVED: To obtain the subject solution useful in treating inflammatory diseases and hemato-neoplastic diseases by dissolving a thalidomide derivative EM12 in an isotonic glucose solution to bring the pH of the resulting solution to a specified level or lower. SOLUTION: This aqueous solution of <=pH 5.5 is obtained by dissolving a thalidomide derivative EM12 [3-(1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6- dione of the formula ] in an isotonic glucose solution; wherein this aqueous solution contain pref. >=0.2 mg/mL of the active ingredient. It is preferable to prepare this solution by adding EM12 to an isotonic glucose solution of pH 4 to 5 followed by shaking the mixture until the EM12 is completely dissolved in the solution followed by treating the resultant solution with ultrasonic wave and then carrying out a filtration under sterile conditions. This aqueous solution thus obtained is usable in a parenterally administrable manner, in particular intravenously administrable manner, its dose being normally 0.1-1 mg/kg.
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