COMPOSITION CONTAINING MULTIFUNCTIONAL PROTEASE INHIBITOR AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To obtain a composition containing a multifunctional protease inhibitor for suppressing the decomposition of Cu/Zn superoxide dismutase-1 enzyme by including the multifunctional protease (hereinafter referred to as MPC) inhibitor and a carrier. SOLUTION: This composition is obtained by including a MPC inhibitor and a pharmaceutically permissible carrier. As the above MPC inhibitor, e.g. a compound of the formula R1 is -C≡N or the like; R2 is H, hydroxyl or a (cyclo)alkyl; R3 is -(CH2)m-NH-C(=N-R5)-NH2 [R5 is -NO2 or the like; (m) is 3-10] or the like; R4 is -CH(CH2-R7)-Q [R7 is phenyl or the like; Q is -CH-R8 (R8 is =O or the like) or the like]; (n) is 3-10} is illustrated. This compound is used as an aqueous physiological buffer solution containing the compound in a proportion of about 0.1-10 w/v% when parenterally administrated. It is administrated usually at a daily dose of about 1μg-1 g, preferably about 0.01-100 mg, per body weight 1 kg.