发明名称 |
Truncated aspartase enzyme derivatives and uses thereof |
摘要 |
Truncated derivatives of aspartase having enhanced catalytic activity and/or enhanced clot dissolution properties relative to native aspartase from E. coli. The enzymes are isolated by site-directed mutagenesis of DNA encoding aspartase. L-aspartic acid is manufactured by contacting fumarate and ammonium ion in the presence of an aspartase derivative.
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申请公布号 |
US6133013(A) |
申请公布日期 |
2000.10.17 |
申请号 |
US19990272114 |
申请日期 |
1999.03.19 |
申请人 |
THE UNIVERSITY OF AKRON |
发明人 |
VIOLA, RONALD E.;JAYASEKERA, MAITHRI M. K.;SARIBAS, ABDULLAH S. |
分类号 |
A61K38/00;A61P7/02;C12N9/88;(IPC1-7):C12N9/88;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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