| 摘要 |
beta -Amino acid derivatives having matrix metalloprotease inhibiting effects, which are compounds represented by general formula (I), optical isomers of the same, pharmaceutically acceptable salts of both, or hydrates of them, wherein R<1> is hydrogen, optionally substituted lower alkyl, or the like; R<2> is a single bond, optionally substituted arylene, or optionally substituted heteroarylene; R<3> is a single bond, -CH=CH-, -CC-, or the like; R<4> is optionally substituted aryl or the like; G<1> and G<2> are each independently hydrogen or the like; and M is hydroxyl or the like. |
