STEREOSELECTIVE MICROBIAL REDUCTION FOR THE PREPARATION OF 1-(4-FLUOROPHENYL)-3(R)-[3(S)-HYDROXY-3-(4-FLUOROPHENYL)PROPYL)]-4(S)-(4-HYDROXYPHENYL)-2-AZETIDINONE

摘要

A process for the stereoselective microbial reduction of compound of formula (II) to compound of formula (I) comprising adding compound of formula (II) t o a medium, medium and buffer, medium and solvent, or medium and a mixture of buffer and solvent containing a microorganism, preferably Rhodococcus fascia ns ATCC No.202210 or fungal isolate Geotrichum candidum ATCC No. 74487, incubating the resulting mixture, and isolating a hydroxy compound of formul a (I), is described. The compound of formula (I) is a serum cholesterol loweri ng agent.