CHEMOKINE-DERIVED SYNTHETIC PEPTIDES

摘要

Synthetic peptide analogs of chemokines are designed to include the N- and C - terminal portions of the corresponding naturally occurring chemokine. In particular, synthetic peptide analogs of stromal cell-derived factor-1 (SDF- 1) are effective in inhibiting HIV-1 entry and infection via the CXC chemokine receptor 4 (CXCR4). Each peptide comprises a peptide segment analog of the S DF- 1 N-terminal region joined to a peptide segment analog of the SDF-1 C-termin al region. The peptides are useful for HIV treatment and prophylaxis.