HUMAN SIGNAL TRANSDUCTION SERINE/THREONINE PROTEIN KINASE

摘要

An isolated and purified human signal transduction serine threonine protein kinase is described. A cDNA sequence which encodes the native signal transduction polypeptide is disclosed as well as the structural coding region and the amino acid residue sequence of the protein kinase. Methods are provided which employ the novel sequences to identify compounds that modulate the biological and/or pharmacological activity of the signal transduction protein kinase and hence regulate cellular and tissue physiology. Biologically-effective antisense molecules, as well as dominant negative mutant versions of the protein kinase, are described which are suitable for therapeutic use. The invention is also related to the diagnosis, study, prevention, and treatment of pathophysiological disorders related to or mediated by the signal transduction molecule.